Engineering Biotransport Processes for Drug Discovery, Delivery and Biomanufacturing
Our research theme is “biotransport phenomana,” which are trasnport processes of matters, momentum, energy and even information through biological systems. We measure, model and understand these processes to engineer new biotechnology and biomaterials. Current research projects include drug and nanoparticle transport in the tumor microenvironment, biomimetic disease models of pancreatic cancer and blood-brain interface for …
He is a Professor of Mechanical and Biomedical Engineering at Purdue University, and is also the Program Leader of Drug Delivery and Molecular Sensing Program at NCI-designated Purdue Center for Cancer Research. He is B.S.F. Schaefer Outstanding Young Faculty Scholar and Discovery Park Fellow. He received his Ph.D. in Mechanical Engineering from the University of Minnesota …
Two new members join the group in Fall 2023 – Ali Alkalin and Eric Williamson. Ali starts his PhD study in Fall 2023. Ali got his BS and MS in mechanical engineering from Middle Eastern Technical University (METU) in Turkey. Interestingly, he was trained by our alum, Dr. Ozcelikkale, during his MS study. Eric also …
Cih’s paper on inkjet printing of tumoroids with tumor-stroma interface is published on the Journal Materials Today Advances. In this work, Cih developed a new 3D printing method, named as “morphogenetic printing”, to rapidly produce tumoroids with extremely high cell density. Inkjet-printed morphogenesis of tumor-stroma interface using bi-cellular bioinks of collagen-poly(N-isopropyl acrylamide-co-methyl methacrylate) mixture Abstract …
Yingnan and Sameep’s paper to establish the mechanosensing mechanism of pain during injection of biologics is published in the Journal Extreme Mechanics Letters. In this paper, mechanical changes in the skin microenvironment are quantified in both experimentally and computationally, and correlated to potential pain signal. Experimental and computational analysis of the injection-induced mechanical changes in …
A collaborative paper by Yingnan with Yoon Yeo’s group is published in the Journal of Controlled Release. In this work, Yingnan reports precise control of diffusion and mixing processes on a microfludic platform to synthesize nanometer thick capsuled various hydrophobic drugs. A timescale-guided microfluidic synthesis of tannic acid-FeIIInetwork nanocapsules of hydrophobic drugs Yingnan Shen, Simseok A. Yuk, Soonbum Kwon, Hassan Tamam, Yoon Yeo, Bumsoo Han Abstract …
Read more “Synthesis of nano-capsuled drug particles using microfluidics”
Hye-ran’s paper on directed cell migration with Andrew Mugler’s group is published on the Journal Lab on a Chip. It is also selected as Lab on a Chip HOT Article 2023. In this work, Hye-ran proposed model migrating cancer cells as digital logic gates to process entangled chemical and fluidic microenvironmental cues. Cells function as …
A comprehensive review paper on computational models of drug transport by Sae Rome with Professor Ozcelikkale’s group at the Middle East Technical University is now published at the Journal Pharmaceutical Research. Predictive Design and Analysis of Drug Transport by Multiscale Computational Models Under Uncertainty Abstract Computational modeling of drug delivery is becoming an indispensable tool …
Read more “A Review on Computational Models of Drug Transport”
Hye-ran is finally hooded for her Ph.D.! Due to COVID, she missed her commencement and hooding ceremony. It is a way overdue, but congratulations!
Cih successfully defended her Ph.D. dissertation, entitled “Drop-on-demand printing of hydrogels from subgroup transport phenomena to functional materials.”
Our Alumnus, Seungman Park, will start his faculty appointment in the Department of Mechanical Engineering at the University of Nevada, Las Vegas (UNLV) from July 2022. He plan to pursue research related to aging. Congratulation and best wishes!