Sae Rome successfully defended her PhD dissertation, entitled “Reprogramming the pancreatic cancer stroma by targeting coagulation at the tumor microenvironment.” In this work, she developed microphysiological model of PDAC stroma with controlled coagulation system, and investigated the role of the extravascular coagulation system in tumor progression, tumor-associated fibrosis and drug resistance. Through her research, she tested and validated therapeutic potential of two specific targets , PAR1 (Protease-Activated Receptor 1) and fibrin across multiple PDAC models.