Pancreatic ductal adenocarcinoma (PDAC) is one of the most challenging cancers to diagnose and treat, largely due to its dense tumor microenvironment. Our latest study in Advanced Science takes a significant step forward by developing DNA origami-cyanine (Do-Cy) nanocomplexes – a novel approach for selectively imaging KRAS-mutant pancreatic cancer cells (PCCs) while excluding cancer-associated fibroblasts (CAFs). By leveraging elevated macropinocytosis, these nanocomplexes ensure precise internalization into PCCs.

Our findings, validated in both engineered in vitro models and xenograft pancreatic cancer models, open the door for more effective, selective, and safer treatment strategies. Precision delivery is the future of cancer therapy. Looking forward to discussions on the implications of this approach for both research and clinical applications! 

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