Author: btp.lab@gmail.com
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Group 2018 at the Clock Tower
Hye-ran, Bumsoo, Cih, Michael, Stephanie, Pei-En, and Sae Rome (Left to right, after a group meeting at 7/20/18)
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About Han Research Group
We are highly dynamic, interactive, collaborative and diverse group of peoples. We study transport phenomena in biological environments, so-called biotransport, to control and engineer the transport of momentum, energy, and chemical species to develop new therapeutics, biotechnologies and biomaterials. Our current research is focused on drug delivery to tumor, cell-fluid-matrix interactions in stromal tissues, and engineering of…
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Microfluidic Metastasis Model
Our work on developing a microfluidic model of cancer cell adhesion during metastasis process is published at Biomicrofluidics. Analysis of adhesion kinetics of cancer cells on inflamed endothelium using a microfluidic platform Taylor J. Thompson and Bumsoo Han Abstract Metastasis is the ultimate cause of death among the vast majority of cancer patients. This process…
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Sae Rome Choi, Ph.D., Postdoc Fellow
Sae Rome is a Postdoc Fellow in Mechanical Science and Engineering as well as Cancer Center at Illinois. She received her Ph.D. in Mechanical Engineering at Purdue University and B.S. in Chemical Engineering from The University of Notre Dame. She is the recipient of the Winkelman-Davidson Fellowship from the Graduate School at Purdue and SIRG…
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2018 PCCR Challenge 5K Run/Walk
Again, our group participate 2018 Challenge 5K Run/Walk to support the Purdue Center for Cancer Research – Bumsoo, Stephanie, Hye-ran and Sean.
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News Highlight of Cell Migration Image
Our microscopy image in our recent article in the Journal of Royal Society Interface is highlighted as “Seven Stunning Cell Images from 2017.” by TechnologyNetworks.com
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News Highlight at Big Ten Network
Our research on microfluidic tumor models are featured at Big Ten Network. Please read the article for details.
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Michael Linnes, Ph.D., Research Scientist
Michael is a research scientist in the Han Group. He received his Ph.D. in Bioengineering from the University of Washington (2009), and B.S. in Biomedical Engineering from the University of Minnesota (2003). His research interests are in tissue engineering and biomaterials. [ap_social facebook=”” twitter=”” gplus=”” linkedin=”https://www.linkedin.com/in/mlinnes/” dribble=””]
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Screening for effective chemotherapy
Our work to screen patient-specific drug efficacy using our microfluidic tumor platform is published in the Journal of Controlled Release. Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model Altug Ozcelikkale, Kyeonggon Shin, Victoria Noe-Kim, Bennett D.Elzey, Zizheng Dong, Jian-Ting Zhang, Kwangmeyung Kim, Ick Chan Kwon, Kinam Park, Bumsoo Han Abstract Successful drug delivery and overcoming drug resistance are the primary clinical challenges for management and treatment of…
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Biophysical models of chemotaxis
A collaborative paper with Professor Mugler’s group at Purdue Physics regarding collective and individual cell migrations induced by chemical gradient is published at Physical Review Letters. Emergent versus Individual-Based Multicellular Chemotaxis Julien Varennes, Sean Fancher, Bumsoo Han, and Andrew Mugler Abstract Multicellular chemotaxis can occur via individually chemotaxing cells that are mechanically coupled. Alternatively, it…
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Group 2017 at the Engineering Fountain
Stephanie, Bumsoo, Hye-Ran, Jingyi, Michael and Cih (right to left, after the group meeting of 10/23/2017)
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Video Clip: En Masse Migration of Fibroblasts
This videoclip shows the deformation of collagen matrix (left, bright fields) and migration of fibroblasts on the matrix (right, fluorescence micrographs). This videoclip illustrate that, when a large number of fibroblasts migrate all together (i.e., en masse), cells can collectively deform the matrices. Fibroblasts are seeded on the left half of each image. The matrix…