Category: Publications
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Precision Imaging of Pancreatic Cancer Cells
A collaborative paper reporting precision imaging of pancreatic cancer cells in the desmoplastic tumor microenvironment using DNA origami-Cy nanocomplex is published with Dr. Jong Hyun Choi’s group in the Journal Advanced Science. In this study, we target KRAS-dependent macropinocytosis to selectively labeling cancer cells. Throughout the study, we also demonstrated that engineered tumor models could…
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Conductive Hydrogel
A collaborative paper with Dr. Tian Li’s lab at Purdue University is published in the Journal Cell Reports Physical Science as below: Conductive hollow hydrogel fibers toward high-sensitivity bio-textiles Pengfei Deng, Zijian He, Yingnan Shen, Noor Mohammad Mohammad, Wenhui Xu, Bumsoo Han and Tian Li Abstract Conductive hydrogels are becoming valuable in creating soft, flexible…
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Drug Discovery using 3D Tumor Models
A collaborative paper with Dr. Melissa Fishel’s Group at Indiana University was published in the Journal Pharmacological Research as below. New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types Silpa Gampala, Hye-ran Moon, Randall Wireman, Jacqueline Peil, Sonia Kiran, Dana K Mitchell, Kylee Brewster, Henry Mang, Andi Masters, Christine Bach,…
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Nanoparticle Manufacturing
Our paper regarding nanoparticle manufacutring using microfluidics are published in the Journal Analyst. The paper is selected as Cover Article and also selected for Analyst Review Articles 2023. Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics Yingnan Shen, Hogyeong Gwak and Bumsoo Han Abstract Numerous innovative nanoparticle formulations of drugs and biologics,…
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MPS as Drug Discovery Tools
Our review paper on the challenges and opportunities of adapting microphysioloigcal systems as drug discovery and evaluation tools are published in the Jounral Biomicrofluidics. Microphysiological systems as reliable drug discovery and evaluation tools: Evolution from innovation to maturity Hye-Ran Moon, Nishanth Surianarayanan, Tarun Singh and Bumsoo Han Abstract Microphysiological systems (MPSs), also known as organ-on-chip…
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Inkjet Printing of Tumors
Cih’s paper on inkjet printing of tumoroids with tumor-stroma interface is published on the Journal Materials Today Advances. In this work, Cih developed a new 3D printing method, named as “morphogenetic printing”, to rapidly produce tumoroids with extremely high cell density. Inkjet-printed morphogenesis of tumor-stroma interface using bi-cellular bioinks of collagen-poly(N-isopropyl acrylamide-co-methyl methacrylate) mixture Abstract…
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Feel the pain…?
Yingnan and Sameep’s paper to establish the mechanosensing mechanism of pain during injection of biologics is published in the Journal Extreme Mechanics Letters. In this paper, mechanical changes in the skin microenvironment are quantified in both experimentally and computationally, and correlated to potential pain signal. Experimental and computational analysis of the injection-induced mechanical changes in…
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Synthesis of nano-capsuled drug particles using microfluidics
A collaborative paper by Yingnan with Yoon Yeo’s group is published in the Journal of Controlled Release. In this work, Yingnan reports precise control of diffusion and mixing processes on a microfludic platform to synthesize nanometer thick capsuled various hydrophobic drugs. A timescale-guided microfluidic synthesis of tannic acid-FeIIInetwork nanocapsules of hydrophobic drugs Yingnan Shen, SimseokA. Yuk, Soonbum Kwon, Hassan Tamam,…
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Cell as a logic gate
Hye-ran’s paper on directed cell migration with Andrew Mugler’s group is published on the Journal Lab on a Chip. It is also selected as Lab on a Chip HOT Article 2023. In this work, Hye-ran proposed model migrating cancer cells as digital logic gates to process entangled chemical and fluidic microenvironmental cues. Cells function as…
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A Review on Computational Models of Drug Transport
A comprehensive review paper on computational models of drug transport by Sae Rome with Professor Ozcelikkale’s group at the Middle East Technical University is now published at the Journal Pharmaceutical Research. Predictive Design and Analysis of Drug Transport by Multiscale Computational Models Under Uncertainty Abstract Computational modeling of drug delivery is becoming an indispensable tool…
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Scaling law for hydrogel printing
Cih’s paper proposing a scaling law and dimensionless parameter for predictively printing particle-laden hydrogel is published in the International Journal of Heat and Mass Transfer. The paper provide a new guideline to print “digital” hydrogel. A scaling law of particle transport in inkjet-printed particle-laden polymeric drops Cih Cheng, Yoon Jae Moon, Jun Young Hwang, George…
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Cell’s signal processing machinery
Hye-ran’s paper collaboratively developed with Dr. Mugler’s group at the University of Pittsburgh is now published in Journal iScience. We studied the cells’ biophysical capacity to decipher complex chemical cues during migration. Signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues Hye-ran Moon, Soutick Saha, Andrew Mugler, and…