Category: Publications
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Cover of Lab on A Chip
Our recent paper on the Journal Lab on a Chip is highlighted as the Journal Cover article. Lab Chip, 2021,21, 3619-3619 The paper regards creation of functional pancreatic acinus model using reprogrammed cancer cells by PTF1a induction. The artwork is developed by Hye-ran.
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Pancreatic Acinus on Chip
Our paper developing a normal pancreatic acinus model is published in Lab on a Chip. In this paper, we reprogram pancreatic cancer cells to create cells with normal phenotypes. Engineering of a functional pancreatic acinus with reprogrammed cancer cells by induced PTF1a expression A pancreatic acinus is a functional unit of the exocrine pancreas producing digest enzymes.…
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Drug discovery for pancreatic cancer: Ref-1 redox activity
A collaborative paper with groups at Indiana University Medical School and Harvard Medical School is published in the Journal of Experimental & Clinical Cancer Research. This paper regards drug discovery for pancreatic cancer focusing on a protein called Ref-1. Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a…
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Engineering of Biomaterials for Tumor Model
A review paper by Sae Rome regarding the engineering biomaterials for tumor modeling is now published at Materials Today Advances. This paper was written with Dr. Joon Kong’s Group at UIUC and Dr. Matt Flick’s Group and UNC. Engineering of biomaterials for tumor modeling Sae Rome Choi, Yi Yang, Kai-Yu Huang, Hyun Joon Kong, Matthew…
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Back Cover of Lab on A Chip
Hye-ran and Altug’s paper in Lab on a Chip is featured as a Back Cover. Lab Chip, 2020,20, 3844-3844 An engineered pancreatic cancer model with intra-tumoral heterogeneity of driver mutations
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Pancreatic Cancer Model with Intra-Tumoral Heterogeneity
Our work on pancreatic cancer model with heterogenous cancer cell population is published in the Journal Lab on a Chip. An engineered pancreatic cancer model with intra-tumoral heterogeneity of driver mutations Hye-ran Moon, Altug Ozcelikkale, Yi Yang, Bennett D. Elzey, Stephen F. Konieczny and Bumsoo Han Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a complex disease…
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Triple-Negative Breast Cancer Model
Our work on microfluidic tumor models of subtype-specific triple-negative breast cancer is published at the Journal PlosONE. Subtype-specific characterization of breast cancer invasion using a microfluidic tumor platformHye-ran Moon, Natalia Ospina-Muñoz, Victoria Noe-Kim, Yi Yang, Bennett D. Elzey, Stephen F. Konieczny, and Bumsoo Han AbstractUnderstanding progression of breast cancers to invasive ductal carcinoma (IDC) can…
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A book chapter on engineered tumor models
Hye-ran’s book chapter reviewing engineered tumor models is published. This chapter is included in the book, entitled “Biomaterials for Cancer Therapeutics” 2nd Edition Evolution and Innovation.
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Tumor Model of Heterogeneous Pancreatic Cancer
Mike and Stephanie’s work regarding PDAC tumor model is published at the Journal “Small.” This paper aims to create an in vitro tumor model reconstituting intratumoral heterogeneity of human pancreatic cancer. This work is based on collaboration with Professor Konieczny’s group in the Department of Biological Science at Purdue. A Biomimetic Tumor Model of…
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Similarity during Hydrogel Printing
Cih’s paper regarding intra- and inter-drop water-matrix interaction during hydrogel printing is accepted for publication in the International Journal of Heat and Mass Transfer. This study proposes a new similarity mechanism of water transport within hydrogel, which will be able to design additive manufacturing processes. This work is based on collaboration with Dr. Jun Young…
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Physical Constraints in Cell Migration
Hye-ran’s paper regarding biophysical constraints in accuracy and persistence in cancer cell chemotaxis is just accepted in PLOS Computational Biology. This study provides a new insight to understand cancer metastasis and develop new therapeutic strategies. This work is based on collaboration with Professor Mugler’s group at Physics. Physical constraints on accuracy and persistence during breast…
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Microfluidic Metastasis Model
Our work on developing a microfluidic model of cancer cell adhesion during metastasis process is published at Biomicrofluidics. Analysis of adhesion kinetics of cancer cells on inflamed endothelium using a microfluidic platform Taylor J. Thompson and Bumsoo Han Abstract Metastasis is the ultimate cause of death among the vast majority of cancer patients. This process…