Category: Publications
-
Screening for effective chemotherapy
Our work to screen patient-specific drug efficacy using our microfluidic tumor platform is published in the Journal of Controlled Release. Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model Altug Ozcelikkale, Kyeonggon Shin, Victoria Noe-Kim, Bennett D.Elzey, Zizheng Dong, Jian-Ting Zhang, Kwangmeyung Kim, Ick Chan Kwon, Kinam Park, Bumsoo Han Abstract Successful drug delivery and overcoming drug resistance are the primary clinical challenges for management and treatment of…
-
Biophysical models of chemotaxis
A collaborative paper with Professor Mugler’s group at Purdue Physics regarding collective and individual cell migrations induced by chemical gradient is published at Physical Review Letters. Emergent versus Individual-Based Multicellular Chemotaxis Julien Varennes, Sean Fancher, Bumsoo Han, and Andrew Mugler Abstract Multicellular chemotaxis can occur via individually chemotaxing cells that are mechanically coupled. Alternatively, it…
-
Group migration of fibroblasts
Our work on massive migration of fibroblasts is published in the Journal of Royal Society Interface. Effects of dynamic matrix remodelling on en masse migration of fibroblasts on collagen matrices Altug Ozcelikkale, J. Craig Dutton, Frederick Grinnell, Bumsoo Han Abstract Fibroblast migration plays a key role during various physiological and pathological processes. Although migration of…
-
ROS-responsive drug carrier
A collaborative paper with Professor Joon Kong’s group at UIUC is published at ASC Applied Materials & Interfaces. Active Antioxidizing Particles for On-Demand Pressure-Driven Molecular Release Yongbeom Seo, Jiayu Leong, Jye Yng Teo, Jennifer W. Mitchell, Martha U. Gillette, Bumsoo Han, Jonghwi Lee, and Hyunjoon Kong Abstract Overproduced reactive oxygen species (ROS) are closely…
-
Intracellular transport for mechanotransduction
A collaborative paper with Professor Sungsoo Na’s group at IUPUI is now published at Scientific Reports. Subcellular domain-dependent molecular hierarchy of SFK and FAK in mechanotransduction and cytokine signaling Qiaoqiao Wan, ThucNhi TruongVo, Hannah E. Steele, Altug Ozcelikkale, Bumsoo Han, Yingxiao Wang, Junghwan Oh , Hiroki Yokota & Sungsoo Na Abstract: Focal adhesion…
-
Cover of WIREs Nanomedicine & Nanotechnology
Altug’s 3D drawing of nanoparticle transport through extracellular matrix from our recent article at WIREs Nanomedicine and Nanotechnology is selected as the Cover Image of the Issue.
-
Enzyme-Induced Matrix Softening
A collaborative paper with Professor Kong’s group at UIUC is now published at Macromolecular Bioscience. Enzyme-Induced Matrix Softening Regulates Hepatocarcinoma Cancer Cell Phenotypes Abstract The progression of cancer is often accompanied by changes in the mechanical properties of an extracellular matrix. However, limited efforts have been made to reproduce these biological events in vitro. To this…
-
Drug and nanomedicine screening platforms
A review paper by Altug, Hye-ran and Michael regarding microfluidic platforms to screen anti-cancer drugs and nano therapeutics is published in WIREs Nanomedicine and Nanobiotechnology. In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles Altug Ozcelikkale, Hye-ran Moon, Michael Linnes and Bumsoo Han ABSTRACT Advances in nanotechnology have enabled numerous types of nanoparticles…
-
Tunable Cellular Microenvironment
A collaborative paper with Professor Hyunjoon Kong’s group at UIUC regarding precise control of cellular microenvironment via tissue-on-chip approach is accepted in ACS Biomaterials Science and Engineering. Modulation of Matrix Softness and Interstitial Flow for 3D Cell Culture Using a Cell-Microenvironment-on-a-Chip System Nicholas Edwin Clay, Kyeonggon Shin, Altug Ozcelikkale, Min Kyung Lee, Max H. Rich, Dong…
-
Cellular Poroelasticity during Freezing
Our work regarding cytoplasmic fluid-structure interaction during cryopreservation of cells and engineered tissues is published in the Journal of the Royal Society Interface. Role of intracellular poroelasticity on freezing-induced deformation of cells in engineered tissues Soham Ghosh, Altug Ozcelikkale, J. Craig Dutton, Bumsoo Han Abstract Freezing of biomaterials is important in a wide variety of…
-
Cell adhesion and migration on nanopetal
A collaborative paper with Professor Tim Fisher’s group on adhesion and migration of cells on graphitic nanopetal structures is published in Materials Letters. Guidance of cell adhesion and migration by graphitic nanopetals on carbon fibers Soham Ghosh, Guoping Xiong, Timothy S. Fisher and Bumsoo Han Abstract Carbon-based nanomaterials have emerged in a wide variety of applications because of…
-
Simulation of Collective Chemotaxis
A collaborative paper with Professor Andrew Mugler’s group in Physics is published in Biophysical Journal, and the result is highlighted at the Journal website (Video). Collective Chemotaxis through Noisy Multicellular Gradient Sensing Julien Varennes, Bumsoo Han, Andrew Mugler Abstract Collective cell migration in response to a chemical cue occurs in many biological processes such…