Category: Current Research Areas
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Transport for Biomanufacturing
In this project, we are working on microfluidics and 3D printing technologies for distributed and agile manufacturing technologies for nucleic acids (i.e, mRNA and DNA)-based nanomaterials and cell-based hydrogels. We are investigation transport of fluidcs and particulates during the manufacturing processes to create biomaterials with advanced functionalities. This is also to address the significant worldwide…
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Information Transport during Cell Migration
Cells are amazing sensory machinery to detect and process highly complex environmental signals in their microenvironment, including chemical (i.e., concentration of molecules), mechanical (i.e., force or displacement), and flow signals. These signals also varies in time and space. Cells need to decipher (i.e., compare, integrate and process) these signals to determine the migration direction. This…
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Transport at the blood-brain interface
The transport in the brain exhibits numerous unique pathophysiological characteristics, including a tightly regulated blood-brain barrier and circadian rhythm. The normal blood-brain barrier precisely controls the transvascular transport of cells, molecules, and drugs. Its permeability periodically fluctuates in accordance with the circadian rhythm. These are precisely orchestrated processes that ultimately impact neuronal activities and cognitive…
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Transport in the PDAC TME
Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent cancer types in pancreatic cancer. PDAC poses a significant unmet clinical need with a dismal 5-year survival rate of 13% in 2024. PDAC is highly desmoplastic tumor, of which 90% of tissue volume is stroma stissue and only 10% is occupied by cancer cells. The stroma consists…
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Research Theme
Our research theme is “biotransport phenomana,” which are trasnport processes of matters, momentum, energy and even information through biological systems. We measure, model and understand these processes to engineer new biotechnology and biomaterials. Current research projects include drug and nanoparticle transport in the tumor microenvironment, biomimetic disease models of pancreatic cancer and blood-brain interface for…