Time-lapsed micrographs of invasion of mouse pancreatic cancer cells from an epithelial duct to the surrounding collagen matrix. This work is published in Bradney et al (2020) Small. This confocal micrograph illustrates the sprouts of invading pancreatic cancer cells are multi-cellular structures rather than morphological changes of a single cell. This image is also published…

This videoclip shows the deformation of collagen matrix (left, bright fields) and migration of fibroblasts on the matrix (right, fluorescence micrographs). This videoclip illustrate that, when a large number of fibroblasts migrate all together (i.e., en masse), cells can collectively deform the matrices. Fibroblasts are seeded on the left half of each image. The matrix…

This video clip is showing dermal equivalents with quantum dot labeled fibroblasts during freezing. The tissue equivalents are exposed to a temperature gradient (-20 degC on the left and 4 degC on the right). When the clip starts, freezing interface moves from left to right. Due to the volumetric expansion of water during freezing, the…

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