Screening for effective chemotherapy

Our work to screen patient-specific drug efficacy using our microfluidic tumor platform is published in the Journal of Controlled Release. Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model Altug Ozcelikkale, Kyeonggon Shin, Victoria Noe-Kim, Bennett D.Elzey, Zizheng Dong, Jian-Ting Zhang,  Kwangmeyung Kim, Ick Chan Kwon, Kinam Park, Bumsoo Han Abstract Successful drug delivery and overcoming drug resistance are the primary clinical challenges for management and treatment of …

Biophysical models of chemotaxis

A collaborative paper with Professor Mugler’s group at Purdue Physics regarding collective and individual cell migrations induced by chemical gradient is published at Physical Review Letters. Emergent versus Individual-Based Multicellular Chemotaxis Julien Varennes, Sean Fancher, Bumsoo Han, and Andrew Mugler Abstract Multicellular chemotaxis can occur via individually chemotaxing cells that are mechanically coupled. Alternatively, it …

Cih Cheng, Ph.D.

Cih received her Ph.D. in Mechanical Engineering on August 2022. She was co-advised by Professor Bumsoo Han and Professor George Chiu. She received her M.S. and B.S. in Mechanical Engineering from National Taiwan University in Taiwan. [ap_social facebook=”” twitter=”” gplus=”” linkedin=”https://www.linkedin.com/in/cih-cheng-682ab49a/” dribble=””]

Sae Rome Choi, Ph.D. Student

Sae Rome is a Ph.D. student in Mechanical Engineering. She is the recipient of the Winkelman-Davidson Fellowship. She received her B.S. in Chemical Engineering from The University of Notre Dame.  She was an undergraduate research assistant during Summer 2018.

Jonathan Huang, M.D./Ph.D. Student

Jonathan is an M.D./Ph.D. student in Indiana Medical Scientist/Engineer Training Program (MSTP). He is co-advised with Professor Yunlong Liu of Indiana University School of Medicine. He completed his undergraduate study at Washington University is St. Louis.

Nishanth Surianarayanan

Nishanth is a Ph.D. student in Mechanical Engineering of Purdue University. He received his M.S. in Mechanical Engineering from the University of California, San Diego and B.S. from Anna University in India.

Video Clip: En Masse Migration of Fibroblasts

This videoclip shows the deformation of collagen matrix (left, bright fields) and migration of fibroblasts on the matrix (right, fluorescence micrographs). This videoclip illustrate that, when a large number of fibroblasts migrate all together (i.e., en masse), cells can collectively deform the matrices. Fibroblasts are seeded on the left half of each image. The matrix …