Tag: biomanufacturing
-
Advancing Precision Imaging in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most challenging cancers to diagnose and treat, largely due to its dense tumor microenvironment. Our latest study in Advanced Science takes a significant step forward by developing DNA origami-cyanine (Do-Cy) nanocomplexes – a novel approach for selectively imaging KRAS-mutant pancreatic cancer cells (PCCs) while excluding cancer-associated fibroblasts (CAFs). By…
-
Inkjet Printing of Tumors
Cih’s paper on inkjet printing of tumoroids with tumor-stroma interface is published on the Journal Materials Today Advances. In this work, Cih developed a new 3D printing method, named as “morphogenetic printing”, to rapidly produce tumoroids with extremely high cell density. Inkjet-printed morphogenesis of tumor-stroma interface using bi-cellular bioinks of collagen-poly(N-isopropyl acrylamide-co-methyl methacrylate) mixture Abstract…
-
Feel the pain…?
Yingnan and Sameep’s paper to establish the mechanosensing mechanism of pain during injection of biologics is published in the Journal Extreme Mechanics Letters. In this paper, mechanical changes in the skin microenvironment are quantified in both experimentally and computationally, and correlated to potential pain signal. Experimental and computational analysis of the injection-induced mechanical changes in…
-
Synthesis of nano-capsuled drug particles using microfluidics
A collaborative paper by Yingnan with Yoon Yeo’s group is published in the Journal of Controlled Release. In this work, Yingnan reports precise control of diffusion and mixing processes on a microfludic platform to synthesize nanometer thick capsuled various hydrophobic drugs. A timescale-guided microfluidic synthesis of tannic acid-FeIIInetwork nanocapsules of hydrophobic drugs Yingnan Shen, SimseokA. Yuk, Soonbum Kwon, Hassan Tamam,…